A domestic refrigerator designed to work with R-134a was used as an investigation unit to asses the prospect of using mixed refrigerants. The recital of the refrigerator using mixed refrigerant was investigated and compared with the performance of refrigerator when R-134a was used as refrigerant. The effect of condenser temperature and evaporator temperature on COP, refrigerating effect was investigated. The energy consumption of the refrigerator during experiment with mixed refrigerant and R-134a was measured. The outcome shows the permanent running and cycling results showed that R134a with a charge of 100 g or mixed refrigerant with charge of 80 mg or more satisfy the required freezer air temperature of - 12°C. The lowest electric energy consumption was achieved using mixed refrigerant with heat level is less than -15°C. This mixture achieved higher volumetric cooling capacity and lower freezer air temperature compared to R134a. Experimental results of the refrigerator using mixed refrigerant were compare with those using R134a. Pull-down time, pressure ratio and power consumption of mixed refrigerant refrigerator were under those of R134a refrigerator by about 7.6%, 5.5% and 4.3%, respectively. Also, actual COP of mixed refrigerant refrigerator was higher than that of R134a by about 7.6%. Lower on-time ratio and energy consumption of mixed refrigerant refrigerator by nearly 14.3% and 10.8%, respectively, compared to those of R134a refrigerator were achieved. The COP and other result obtain in this experiment show a positive indication of using mixed refrigerant as refrigerants in household refrigerator.