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TITLE : TAXONOMY, FERMENTATION, BIOLOGICAL ACTIVITY, ISOLATION AND CHARACTERIZATION OF COMPOUND FROM A NEW STRAIN Streptomyces  
AUTHORS : Sudha. S      Masilamani Selvam . M            
ABSTRACT :

An Actinomycetes isolate SU 4 active against clinical fungal pathogen was isolated from the coastal soil sample of Veerampattinam, Pondicherry. Based on morphological and biochemical characteristics it was identified as Streptomyces coelicolor also submitted to GENBANK with the accession number JQ828940 as Streptomyces coelicolor strain SU 6. The active compound isolated from Streptomyces coelicolor strain SU 6 by submerged fermentation using ISP-2 medium was characterized based on spectral data. The following compounds diisobutyl phthalate (16.82%) and 1,2-Benzenedicaarboxylic acid, Bis(2-ehtylehexyl) ester (65.26%) were found abundantly with retention time 15.645, 21.620 respectively. Crude extract of the active isolate exhibited LC50 in 62.5 p.g against Hep-2 cell line, < 250|_ig in VERO cell line. This study clearly proves that the marine sediment derived actinomycetes with bioactive metabolites can be expected to provide high quality biological material for high throughout biochemical and anticancer screening programs.

 
Keywords: Actinobacteria, Biocombatability, Anti-tumor activity, antifungal activity.
 
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